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Manufacturer: Sun Pharmaceutical Industries Ltd. 

Active Ingredient: Amoxicillin

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What is Amoxil

Amoxil is a broad spectrum antibiotic of synthetic origin from the group of penicillins and beta-lactam antibiotics, used for systemic therapy.

Pharmachologic effect

It has a therapeutic effect in relation to gram-negative and gram-positive pathogens. Amoxicillin is characterized by low resistance to lactamases, disintegrating under their influence, therefore, does not affect the pathogenic microflora synthesizing this substance.

Clavulanic acid protects the active substance from the negative effects of lactamases, preventing its breakdown and expanding the spectrum of the antibiotic’s effect on infectious microorganisms.

Pharmacokinetics

The maximum concentration of antibiotic in blood plasma is reached 1 hour after taking the medicine. To improve the absorption process, it is recommended to take the drug immediately before the main meal.

The percentage of binding to plasma proteins is low, more than 70% of the components are unbound in the plasma.

Indications for use

The antibiotic is used in the treatment of diseases of a bacterial and infectious nature in children and adult patients:

  • sinusitis of bacterial origin;
  • otitis media in the acute course;
  • chronic bronchitis during exacerbation;
  • community-acquired pneumonia;
  • infectious inflammation of the bladder;
  • acute and chronic pyelonephritis;
  • skin infections;
  • infection of the bone and articular tissue; osteomyelitis.

It is used in the treatment of cellulitis caused by an animal bite with infection.

The drug is used to treat sinusitis of bacterial origin.

Amoxil is used in the treatment of otitis media.

Chronic bronchitis is an indication for the use of the drug.

Amoxil is used in the treatment of infectious inflammation of the bladder.

It is used in the treatment of cellulitis caused by an animal bite with infection.

The medication is prescribed for infection of the joint tissue.

Contraindications

Individual sensitivity to individual components of the antibiotic, manifested in intense allergic reactions, hypersensitivity to all antibacterial penicillin medicines

Carefully

Limitations to the use of the antibiotic are such clinical cases as Botkin’s disease, deviations in kidney and liver function, which were caused by taking medications with amoxicillin or clavulanic acid in the composition.

How to take Amoxil?

Instructions for use give the average recommended doses of the antibiotic, which can be adjusted individually, depending on the clinical case.

Adults and children with a body weight of 40 kg or more – 2 tablets per day, divided into 2 times, or 250 mg of clavulanic acid and 1750 mg of amoxicillin.

Children and patients with a weight category of less than 40 kg – daily maximum – from 1000 to 2800 mg of amoxicillin and from 143 to 400 mg of clavulanic acid, or from 25 mg / 3.6 mg to 45 mg / 6.4 mg per kg of body weight per day , which are divided into 2 doses.

Taking an antibiotic is not recommended for longer than 14 days. If there is a need for a longer treatment, diagnostics are required to assess the health of the patient and the functioning of the internal organs.

Take the tablets whole, do not chew and drink plenty of fluids. To reduce the likelihood of side effects and improve the absorption of the components of the drug, it is recommended to take the medication before meals.

In severe clinical cases, the antibiotic is taken every 6 hours, dividing the maximum daily dosage by 3 times.

With diabetes

There is no data on the effect of the antibacterial agent on glucose levels. Patients with diabetes do not need dose adjustment.

Side effects

Common side effects that occur during the use of Amoxil, as well as other drugs with an antibacterial spectrum of activity – cutaneous candidiasis, intestinal dysbiosis, and vagina.

  • During treatment with the drug, digestive disorders may be disturbing.
  • In some cases, Amoxil provokes nausea with vomiting.
  • The drug causes diarrhea.
  • In rare cases, patients complained of headaches and dizziness.

Gastrointestinal tract
Often – digestive disorders, manifested in the form of diarrhea, nausea with vomiting. The occurrence of nausea and vomiting is associated with the use of a high dosage of an antibiotic. When such symptoms appear, it is necessary to adjust the amount of the drug. In rare cases, patients have colitis of the pseudomembranous and hemorrhagic type.

Hematopoietic organs
Thrombocytopenia, leukopenia is extremely rare. The rarest cases of adverse symptoms: prolonged bleeding, the development of hemolytic type anemia.

Central nervous system
Rarely – bouts of headache and dizziness, stress, great psychological stress on the background of emotional instability. The rarest cases are reverse-type hyperreactivity, the development of aseptic type meningitis, and convulsions.

From the urinary system
Very rarely – interstitial nephritis.

Allergies
The development of allergies while taking Amoxil is a rarity. Hives and skin rashes, itching are possible. Rarely – the appearance of erythema of the polymorphic type.

Special instructions

Before prescribing an antibiotic, it is necessary to carefully study the patient’s history for the detection of intolerance to antibiotics from the penicillin group. If this information is missing, an allergy test is performed. Reception of Amoxil by people with hypersensitivity to penicillins can lead to the development of serious complications and side effects, up to a fatal outcome.

The drug is not recommended for use in the treatment of pneumonia provoked by penicillin-resistant microorganisms. If it is confirmed that the disease is provoked by a pathogen that is highly sensitive to amoxicillin, it is recommended to switch from a combination of amoxicillin with clavulanic acid to one amoxicillin.

A medication is not prescribed when there is a suspicion of the development of an infectious type of mononucleosis in the patient, since a likelihood of a measles-like rash is high.

Taking an antibiotic for more than 2 weeks can provoke an increase in the resistance of pathogenic microflora to the drug, and therefore it will be necessary to replace the drug with a stronger antibiotic.

Older people (mostly men) have a risk of developing hepatitis. The symptomatic picture of the disease occurs immediately or at the end of the treatment course. The appearance of pathology is associated with the presence of chronic liver diseases in the patient or the simultaneous use of other drugs that adversely affect the condition and functioning of the organ.

With complex therapy with Amoxil and other antibiotics from the group of cephalosporins and penicillins, there is a likelihood of cholestatic jaundice. These side effects are reversible, in most cases pass independently or require symptomatic treatment.

Alcohol compatibility

It is strictly forbidden to consume alcoholic beverages during antibiotic therapy.

Impact on the ability to control mechanisms

Studies on the ability to drive a car and work with complex mechanisms when taking an antibiotic have not been conducted. Considering the risks of negative effects of the active components on the central nervous system and the occurrence of undesirable reactions in the form of dizziness and seizures while driving, it is recommended to refrain from this type of activity.

Use during pregnancy and lactation

An antibiotic in the initial stages of pregnancy is undesirable. Exceptions are cases where other antibacterial drugs cannot provide the necessary therapeutic effect, and the benefits of taking the medication exceed the risks of possible complications.

The drug is absorbed into breast milk, it is forbidden to use it for a nursing woman, the child may experience complications from the digestive system.

Prescribing Amoxil to children

An antibiotic is not prescribed for newborns. The limitation is up to 12 years. From the age of 12, it is possible to take only according to indications with a minimum dosage of 60 mg.

Use in old age

Dose adjustment is not needed. An exception is chronic kidney disease, in which case the dosage is selected individually.